- Windows 7 Pro and Ultimate (Fully Supported in KEPServerEX Version 5)
- Windows Server 2008 R2 * (Fully Supported in KEPServerEX Version 5)
- Windows Server 2008 * (Fully Supported in KEPServerEX Version 5)
- Windows Vista Business/Ultimate* (Fully Supported in KEPServerEX Version 5)
- Windows Server 2003 (SP2 strongly Recommended for Industrial Settings.)
- Windows XP (SP2 strongly Recommended for Industrial Settings.)
- Windows 2000 ** (SP4 strongly Recommended for Industrial Settings.)
* Note: Running Kepware Products on Vista and Server 2008
** Note: In June 2012, with our 5.9 release of KEPServerEX, we will be dropping support for Windows 2000.