No, Kepware does not support the OPC Security specification at this time. To restrict who can connect to and request data from the server, users should disable all forms of connectivity in the server except for OPC. Then, they can set the DCOM security OPC Access and Launch permissions specifically for the Kepware application.
Note: For Ethernet protocols, users can utilize multiple NICs in the PC that is running the OPC server, binding one card to the device network and the other card to the data network. This ensures that all connectivity to the PLC goes through the OPC server. Serial connections are already protected in this fashion.