Yes, it is possible to create a Windows Presentation Foundation (WPF) project using ClientAce. Although the Form Controls that are provided with the ClientAce installation are disabled when a WPF form is created, it is because the controls are standard Windows Form Controls and are not WPF Form Controls. The ClientAce APIs will work without issue in a WPF form.
Note: Although this article was written using ClientAce version 3.5, the same procedures may be applied with ClientAce version 4.0. For a demonstration and more information, download the attached ClientAce WPF Project Example and WPF API Example.